EIF3C Antibody, HRP conjugated

Datasheet

Code	CSB-PA857867LB01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) EIF3C Polyclonal antibody

Uniprot No.

Q99613

Target Names

EIF3C

Alternative Names

Cell migration inducing protein 17 antibody; eIF 3c antibody; eIF3 p110 antibody; eIF3-p110 antibody; eIF3c antibody; EIF3C_HUMAN antibody; EIF3CL antibody; EIF3S8 antibody; EIF3S8 protein antibody; Eukaryotic translation initiation factor 3 subunit 8 (110kD) antibody; Eukaryotic translation initiation factor 3 subunit 8 110kDa antibody; Eukaryotic translation initiation factor 3 subunit 8 antibody; Eukaryotic translation initiation factor 3 subunit C antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Eukaryotic translation initiation factor 3 subunit C protein (201-500AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Gene References into Functions

In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity. PMID: 28854163
High eIF3c expression is positively associated with KRAS. PMID: 28231410
These findings suggest that eIF3c is overexpressed in human gliomas and essential for their proliferation and survival. PMID: 25823503
eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. PMID: 24092755
Collectively, eIF3c deletion effectively reduced the survival of colon cancer cells and could be used as a therapeutic tool for colon cancer therapy. PMID: 23733421
These results indicate that the interaction between Hsp90 and eIF3c may play an important role in hepatitis C virus internal ribosome entry site-mediated translation. PMID: 22016036

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Subcellular Location

Cytoplasm.

Protein Families

EIF-3 subunit C family

Database Links

HGNC: 3279

OMIM: 603916

KEGG: hsa:8663

STRING: 9606.ENSP00000332604

UniGene: Hs.567374

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Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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